User:
Lyman-Kutcher-Burman Model (NTCP)
Definition 
The Lyman-Kutcher-Burman model seeks to estimate the probability of complications in healthy tissue (NTCP) by delivering a probability curve according to the dose:
ID:(2715, 0)
Data Model LKB
Image
The typical data of the LKB model are the exponent
Organo | N | M | TD50
Eur-lex.europa.eu eur-lex.europa.eu
Joint and jaw | 0.07 | 0.1 | 72
Femoral head and neck | 0.25 | 0.12 | 65
Thoracic box | 0.1 | 0.21 | 68
Equine Tail | 0.03 | 0,12 | 75
Brain | 0.25 | 0.15 | 60
Brain, brain stem | 0.16 | 0.14 | 65
Colon | 0.17 | 0.11 | 55
Heart | 0.35 | 0.1 | 48
Laryngeal-laryngeal edema | 0.11 | 0.075 | 80
Esophagus | 0.06 | 0,11 | 68
Stomach | 0.15 | 0.14 | 65
Liver | 0.32 | 0.15 | 40
Small Intestine | 0.15 | 0.16 | 55
Lens | 0.3 | 0.27 | 18
Spinal cord | 0.05 | 0.175 | 66.5
Cartilage necrosis of the larynx | 0.08 | 0.17 | 70
Optic nerve | 0.25 | 0.14 | 65
Ear, Acute Serous Otitis | 0,01 | 0.15 | 40
Ear, chronic otitis | 0.01 | 0.095 | 65
Parótida | 0.7 | 0,18 | 46
Leather | 0.1 | 0.12 | 70
Brachial plexus | 0.03 | 0.12 | 75
Lungs (both combined) | 0.87 | 0.18 | 24.5
Optical chiasm | 0.25 | 0.14 | 65
Rectum | 0.12 | 0,15 | 80
Retina | 0.2 | 0,19 | 65
Kidney | 0.7 | 0.1 | 28
Thyroid | 0.22 | 0.26 | 80
Bladder | 0.5 | 0.11 | 80
From Burman C, Kutcher G J, Emami B and Goitein M 1991 Fitting of normal tissue tolerance data to an analytic function Int. J. Radiat. Oncol. Biol. Phys.
ID:(8816, 0)
Lyman-Kutcher-Burman Simulator (NTCP)
Note
The NTCP according to the LKB model is diagrammed for different
ID:(8817, 0)
Modelo de Lyman-Kutcher-Burman
Storyboard
Variables
Calculations
to 
,
then, select the variable: 
to 
Calculations
Variable
Given
Calculate
Target :
Equation
To be used
Equations
Examples
The Lyman-Kutcher-Burman model seeks to estimate the probability of complications in healthy tissue (NTCP) by delivering a probability curve according to the dose:
The estimation of the probability of complications in the Lyman Kutcher Burman Model (LKB) assuming that the probability of failure can be represented as a gauseana around dose
The probability of failure of an organ is estimated based on the deviation of the effective dose calculated for the healthy tissue
The
The integral of the Gaussian can be approximated by the expression
so it is necessary that in the first approximation the NTCP is:
The dose is calculated by considering the fraction of the
Thus, the effective dose is:
where
The typical data of the LKB model are the exponent
Organo | N | M | TD50
Eur-lex.europa.eu eur-lex.europa.eu
Joint and jaw | 0.07 | 0.1 | 72
Femoral head and neck | 0.25 | 0.12 | 65
Thoracic box | 0.1 | 0.21 | 68
Equine Tail | 0.03 | 0,12 | 75
Brain | 0.25 | 0.15 | 60
Brain, brain stem | 0.16 | 0.14 | 65
Colon | 0.17 | 0.11 | 55
Heart | 0.35 | 0.1 | 48
Laryngeal-laryngeal edema | 0.11 | 0.075 | 80
Esophagus | 0.06 | 0,11 | 68
Stomach | 0.15 | 0.14 | 65
Liver | 0.32 | 0.15 | 40
Small Intestine | 0.15 | 0.16 | 55
Lens | 0.3 | 0.27 | 18
Spinal cord | 0.05 | 0.175 | 66.5
Cartilage necrosis of the larynx | 0.08 | 0.17 | 70
Optic nerve | 0.25 | 0.14 | 65
Ear, Acute Serous Otitis | 0,01 | 0.15 | 40
Ear, chronic otitis | 0.01 | 0.095 | 65
Par tida | 0.7 | 0,18 | 46
Leather | 0.1 | 0.12 | 70
Brachial plexus | 0.03 | 0.12 | 75
Lungs (both combined) | 0.87 | 0.18 | 24.5
Optical chiasm | 0.25 | 0.14 | 65
Rectum | 0.12 | 0,15 | 80
Retina | 0.2 | 0,19 | 65
Kidney | 0.7 | 0.1 | 28
Thyroid | 0.22 | 0.26 | 80
Bladder | 0.5 | 0.11 | 80
From Burman C, Kutcher G J, Emami B and Goitein M 1991 Fitting of normal tissue tolerance data to an analytic function Int. J. Radiat. Oncol. Biol. Phys.
The NTCP according to the LKB model is diagrammed for different
ID:(855, 0)